TLR-mediated immune activation is a strong suppressor of the Treg-attracting chemokine CCL22
نویسندگان
چکیده
Abstract The immunoregulatory chemokine CCL22 is mainly secreted by dendritic cells (DC) in lymph nodes and plays a crucial role maintaining the balance between immune tolerance efficient response induction of intercellular contacts DC regulatory T (Treg) expressing only so far known receptor CCR4. In absence CCL22, to vaccination cancer has been proven be enhanced. this work, we aimed understand how activation Toll-like receptors (TLR) modulates levels mechanistically vitro vivo. We observed that bacterial infection with salmonella typhimurium treatment different TLR agonists such as Poly (I:C), LPS, R848 CpG led potent long-lasting suppression systemic Furthermore, using co-cultures DC, B cells, identified TLR-mediated mediated soluble factors derived from non-DC. Additionally, pursued investigate underlying mechanism could show particularly driven redundant action IL-10, IFN-α IFN-γ. Moreover, inhibition NF-κB reverted CCL22-suppressing effect on splenocytes. CpG-treated mice, Treg/DC were diminished level Ccl22 −/−mice, an observation which links immunological relevance. Taken together, demonstrate signaling results downregulation via cytokines, potentially important enable strong pathogen clearance setting microbial infection.
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.167.27